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Non Competitive Inhibitor Example. Secondary plots for uncompetitive inhibition. This reaction can be used to halt metabolic processes in dangerous organisms. By itself it is a harmless substance but it is broken down in the body into. Competitive and non-competitive inhibitors can affect the reaction rates in a metabolic pathway.
Uncompetitive inhibition typically occurs in reactions with two or more substrates or products. 121 is a non-nucleoside inhibitor of the DNA polymerases of herpesviruses and hepatitis B as well as the reverse transcriptase of HIV. By itself it is a harmless substance but it is broken down in the body into. A classic example of competitive inhibition is the effect of malonate on the enzyme activity of succinate dehydrogenase Figure PageIndex1. It results in destruction of enzyme activity. Examples of a Non-competitive Inhibitor Allosteric Strychnine Is a colorless highly toxic alkaloid that causes muscular convulsions and eventual death through asphyxia.
Examples of non-competitive inhibitors include cyanide mercury and silver.
For example the amino acid alanine noncompetitively inhibits the enzyme pyruvate kinase. While uncompetitive inhibition requires that an enzyme-substrate complex must be formed non-competitive. Strychnine binds to glycine receptors preventing glycine an inhibitory neurotransmiter from binding. Lead for example can block the enzyme that puts iron into hemoglobin precursors. Examples of non-competitive inhibitors include cyanide mercury and silver. Secondary plots for uncompetitive inhibition.