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Hpv Mrna E6 E7 Detected What Does That Mean. Likewise HPV test results can either be positive meaning that a patients cervical cells are infected with one or more of a group of high-risk HPV types which is what most commercially available HPV tests detect or negative indicating that none of the high-risk HPV types were found. Persistent infection with human papillomavirus HPV is the principal cause of cervical cancer and its precursor cervical intraepithelial neoplasia CIN1-3 The presence of HPV has been implicated in more than 99 of cervical cancers worldwide. There are several published works that mention the detection of HPV 16 E6 E7 transcripts in metastatic lymph node 25-27 they have applied RT-PCR techniques in fixed samples. Several HPV tests are specific for HPV16 and HPV18the types that cause most cervical cancers.
A positive HPV E6E7 mRNA testing result suggested the women with ASCUS or LSIL Pap smear was in a truly dangerous position which is an adverse prognostic factor. The E6 and E7 mRNA detection assay PreTect HPV-Proofer based on real-time multiplex NASBA as well as a separate real-time multiplex NASBA assay were used to study E6 and E7 mRNA expression from HPV types 16 18 31 33 35 45 52 and 58 which are the most prevalent high-risk HPV types in Europe and North America. Commercial assays for simultaneous genotyping and detection of E6E7 mRNA from the five most common high-risk HPV types are now available and require further. The E6E7 mRNA test showed a higher prevalence of E6 and E7 transcripts in patients with higher-grade lesions. The genome organization and protein structure of E6 and E7 have been discussed followed by their mechanism to establish the six major cancer hallmarks in cervical tissues for tumor propagation. High-risk HPV E6E7 mRNA a level of HPV mRNA below the detection limit of the assay or presence of a genotype other than those listed above.
A negative HPV test means you do not have an HPV type that is linked to cervical cancer.
Most published studies referred to the detection HPV mRNA E6-E7 are related to cervical tissue disease and management. Youll have to do further research on this assay to understand how they differentiate between the different strains because I dont feel like doing that right now. The results were compared to those of consensus. But a WNL pap result. What does this mean. Most published studies referred to the detection HPV mRNA E6-E7 are related to cervical tissue disease and management.