27
Mar
Drugs That Cross Bbb. Efflux pumps may reduce the amount of NPs retained in brain parenchyma. The McLain group have studied a variety of drugs at ISIS that are able to cross the BBB including cocaine and alprazolam. As the molecular structure of the BBB is better elucidated several key approaches for brain targeting include physiological transport mechanisms such as adsorptive-mediated transcytosis inhibition of active efflux pumps receptor-mediated transport cell-mediated endocytosis and the use of peptide vectors. In the broadest sense moderately lipophilic drugs cross the BBB by passive diffusion and the hydrogen bonding properties of drugs can significantly influence their CNS uptake profiles.
Neuroactive drugs are required to cross the BBB to function. Small lipid-soluble agents such as antidepressants cross the BBB via diffusion through endothelial cells. Some chemotherapy agents can pass through the BBB to attack cancer cells. Several approaches have been investigated to allow therapeutics to cross the BBB. This effect of antidepressants may not be achieved by their primary action on proliferating cells but may involve the drug-triggered mobilization of trophic factors such as brain-derived neurotrophic factor BDNF glia-derived protein S100 beta or. Examples of drugs that cross the BBB.
Neuroactive drugs are required to cross the BBB to function.
The uptake rate across the BBB for an endogenous ligand of a transporter is roughly about 10 times higher than would be expected if it crossed by transmembrane diffusion 18. Efflux pumps may reduce the amount of NPs retained in brain parenchyma. The uptake rate across the BBB for an endogenous ligand of a transporter is roughly about 10 times higher than would be expected if it crossed by transmembrane diffusion 18. Neuroactive drugs are required to cross the BBB to function. NPs coated with molecules such as albumin or chitosan can cross the BBB by adsorptive transcytosis. Some chemotherapy agents can pass through the BBB to attack cancer cells.